|garage DNA ..what a mess?|
Also it appears that the chromosomes near the nuclear periphery are more quiescent than chromosomes near the center. The chromosomes in the center are more involved in gene expression. No one knows how the chromosomes get directed toward a specific place in the nucleus. I find it quite amazing that this overall structure can be maintained because there is so much DNA in the nucleus. Remember in its stretched out form DNA is hundreds of thousands of times longer than the nucleus diameter. I have trouble just keeping a few power cords untangled in the garage. Just imagine my garage packed full of tightly wound-up and partially wound-up power cords and that I need to find one cord in particular to unwind and use and I must do this while literally swimming through a tangled maize of power cords. I think you would suffer from "power cord" entrapment before you could even reach the power cord you need.
1 Investigate progeria and hypothesize how nuclear organization could lead to this syndrome and other disease states. Many diseases are related to chromosome structure and function including cancer, does this support the notion of bad design?....i.e., does the fact that some aspects of cell structure are more involved in promoting disease states show that a designer of the cell or life is unlikely ?
2 Describe how nuclear organization and chromosome location could evolve during the evolution of the nucleus from a prokaryote ancestor? What are some of hurdles that evolution would have to overcome?